alas there is no support for xbox360 controller for bioshock 2,i spent a little while doing one and i think its quite good,ammo changing is a little tricky in a firefight though but its open to tweaking....
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;--- Xpadder Profile Data ---
Version=5.6
Name=bio2
KeyTapTime=14
Set1StickDeadZones=128,108
Set1StickDiagonalSizes=45,42
Set1Button1Slots=F
Set1Button2Slots=B
Set1Button3Slots=R
Set1Button4Slots=Space
Set1Button5Slots=Alt
Set1Button5SetSelect=1
Set1Button6Slots=T
Set1Button7Slots=M
Set1Button8Slots=Escape
Set1Button9Slots=C
Set1Button10Slots=Left Shift
Set1DPadUpSlots=Q
Set1DPadRightSlots=Mouse Wheel Down
Set1DPadDownSlots=Right Control
Set1DPadLeftSlots=Mouse Wheel Up
Set1Stick1UpSlots=W
Set1Stick1RightSlots=D
Set1Stick1DownSlots=S
Set1Stick1LeftSlots=A
Set1Stick2UpSlots=Mouse Move Up
Set1Stick2UpMouseSpeed=21
Set1Stick2RightSlots=Mouse Move Right
Set1Stick2RightMouseSpeed=21
Set1Stick2DownSlots=Mouse Move Down
Set1Stick2DownMouseSpeed=21
Set1Stick2LeftSlots=Mouse Move Left
Set1Stick2LeftMouseSpeed=21
Set1TriggerLeftSlots=Right Mouse Button (2)
Set1TriggerRightSlots=Left Mouse Button (1)
Set2Button1Slots=F
Set2Button2Slots=B
Set2Button3Slots=R
Set2Button4Slots=Space
Set2Button5Slots=Alt
Set2Button5SetSelect=0
Set2Button6Slots=T
Set2Button7Slots=L
Set2Button8Slots=Escape
Set2Button9Slots=C
Set2Button10Slots=Left Shift
Set2DPadUpSlots=Left Square Bracket
Set2DPadRightSlots=Right Square Bracket
Set2DPadDownSlots=J
Set2DPadLeftSlots=Left Square Bracket
Set2Stick1UpSlots=W
Set2Stick1RightSlots=D
Set2Stick1DownSlots=S
Set2Stick1LeftSlots=A
Set2Stick2UpSlots=Mouse Move Up
Set2Stick2UpMouseSpeed=32
Set2Stick2RightSlots=Mouse Move Right
Set2Stick2RightMouseSpeed=32
Set2Stick2DownSlots=Mouse Move Down
Set2Stick2DownMouseSpeed=32
Set2Stick2LeftSlots=Mouse Move Left
Set2Stick2LeftMouseSpeed=32
Set2TriggerLeftSlots=Right Mouse Button (2)
Set2TriggerRightSlots=Left Mouse Button (1)
dpad up is plasmid changing left and right are weapon cycle and dpad down is use medikit
top left bumper is alt and switch selecter on the dpad for ammo changing and exiting scout mode and the back button switches between the map and playing the diaries...control system layout is very similar to bioshock 1 on the xbox 360.
enjoy.